Scientists at the University of Vienna discovered that ancient genome reorganization in cephalopods (octopuses, squid, cuttlefish) reshaped 3D DNA structure, bringing distant chromosomal regions into contact and creating new gene regulatory networks. This process, called 'regulatory entanglement,' may explain how these animals evolved their exceptionally complex nervous systems capable of problem-solving and camouflage. The findings suggest that 3D genome organization actively shapes evolutionary processes rather than being merely a passive consequence.