Lazzaro et al. from Dartmouth present a programmable readout (PRO) pixel architecture for image sensors that can be reconfigured to optimize for low noise, high speed, or high dynamic range by routing photogenerated charge to different in-pixel amplifiers via a CCD router. A test chip with a 36×94 array demonstrates the concept using floating diffusion and floating gate amplifiers, with preliminary images showing distinct performance characteristics across different exposure times and readout modes.