BioNeMo Inference Runtime (BioIR) is NVIDIA's GPU-accelerated library for protein structure prediction, converting FASTA/MSA inputs to PDB/mmCIF outputs using AlphaFold-lineage models. It requires Linux with NVIDIA GPU, Python 3.12, CUDA driver 580+, and is available via PyPI with precompiled kernels for supported architectures including H100, A100, and GB200.